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Evolution of gene position: chromosomal arrangement and sequence comparison of the Drosophila melanogaster and Drosophila virilis sina and Rh4 genes.

机译:基因位置的演变:果蝇,果蝇和Rh4基因的染色体排列和序列比较。

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摘要

The seven in absentia (sina) gene of Drosophila encodes a nuclear protein required for normal eye development. In Drosophila melanogaster, the sina gene is located within an intron of the Rh4 opsin gene. We examine here the nucleotide sequences and chromosomal arrangements of these genes in Drosophila virilis. An interspecies comparison between D. melanogaster and D. virilis reveals that the protein-coding sequences of the sina and Rh4 genes are highly conserved, but the relative chromosomal position and structural arrangement of these genes differ between the two species. In particular, the sina and Rh4 genes are widely separated in D. virilis, and there is no intron in the Rh4 gene. Our results suggest that the Rh4 gene was translocated to another chromosomal location by a retrotransposition event.
机译:果蝇的七个缺席(sina)基因编码正常眼睛发育所需的核蛋白。在果蝇中,sina基因位于Rh4 opsin基因的内含子内。我们在这里检查果蝇果蝇中这些基因的核苷酸序列和染色体排列。种间比较D. melanogaster和D. virilis发现,sina和Rh4基因的蛋白质编码序列是高度保守的,但是这两个基因之间的相对染色体位置和结构排列是不同的。尤其是,鼻窦和Rh4基因在维氏梭菌中广泛分离,并且Rh4基因中没有内含子。我们的结果表明,Rh4基因通过逆转座事件转移到另一个染色体位置。

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